Moderate evidenceGeneral health

Omega-3 (EPA/DHA)

Essential fatty acids from fish oil. Consistently lower triglycerides; effects on cardiovascular events depend on dose and population.

What the science says

Triglyceride reduction Strong evidence
Doses of 2–4 g/day of EPA/DHA lower plasma triglycerides consistently and dose-dependently (typical reduction of 15–30%).
Cardiovascular protection Moderate evidence
Mixed results: the REDUCE-IT trial showed fewer cardiovascular events with high-dose purified EPA (4 g/day) in high-risk patients, but meta-analyses of low-dose supplementation show little or no effect in the general population.
Mood and cognition benefits Limited evidence
Some studies suggest a modest adjunct effect in depression (mainly EPA-rich formulas), but evidence for memory and dementia prevention is weak.

Dosage & safety

Studied dose1–2 g/day of combined EPA+DHA for general health; higher doses only under medical guidance. Prefer products with third-party purity certification.

SafetyWell tolerated. High doses may cause gastrointestinal discomfort and slightly increase the risk of bleeding and of atrial fibrillation in susceptible people.

Scientific references

Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia (REDUCE-IT)
Bhatt DL et al. — New England Journal of Medicine, 2019
Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events
Mozaffarian D, Wu JH — Journal of the American College of Cardiology, 2011

Where to buy

California Gold Nutrition, Omega-3 Premium Fish Oil, 100 Fish Gelatin Softgels (1,100 mg per Softgel)

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Related in General health

Vitamin D3 Strong evidence
Vitamin B12 Strong evidence
Multivitamin Limited evidence
Iron Strong evidence
Iodine Moderate evidence
NAC (N-Acetylcysteine) Moderate evidence