Supplement analysis backed by scientific evidence · PT

← All supplements
Limited evidencePhysical performance

Isomaltulose (Palatinose)

A slowly digested sugar sold as steady endurance fuel. It reliably produces a flatter glucose curve, but that has not translated into better performance in the trials that measured it.

Evidence last reviewed: August 2026

What the science says

  • Flatter glucose and insulin response Moderate evidence

    A double-blind randomised crossover trial before prolonged aerobic exercise confirmed isomaltulose produces lower and more sustained glucose and insulin responses than high-glycemic carbohydrate, with greater fat oxidation.

  • Performance benefit not demonstrated Limited evidence

    In that same randomised crossover trial the metabolic differences did not produce better performance in the exercise bout that followed.

  • Narrow niches with specific evidence Limited evidence

    Small randomised trials have examined isomaltulose before exercise in adults with type 1 diabetes on automated insulin delivery, and inside glycerol-based hyperhydration drinks, with modest and situation-specific effects.

Dosage & safety

Studied dose25–75 g taken 45–60 minutes before endurance exercise in trials. During exercise it is usually blended with faster carbohydrates rather than used alone.
SafetyDigested to glucose and fructose, so it is not calorie-free and is unsuitable in hereditary fructose intolerance. Slow digestion can cause bloating or loose stools at larger doses. It still raises blood glucose, just more gradually.

Scientific references

Where to buy

View on iHerb

Referral link — this site may earn a commission on purchases.

Related in Physical performance