Arginine Silicate (Nitrosigine)
A bonded arginine-silicate complex that raises blood arginine more than arginine alone. The published trials are small, mostly manufacturer-funded, and measure cognition or vasodilation rather than training outcomes.
Evidence last reviewed: August 2026
What the science says
- Acute vasodilation Limited evidence
A randomised trial in young adults found acute arginine silicate produced measurable vasodilation, in the same direction as citrulline malate. This was a single small acute study.
- Cognitive measures in small trials Limited evidence
Randomised double-blind studies in physically active adults and in gamers reported improvements on some cognitive and executive function tests. Samples were small and the work was funded by the ingredient manufacturer.
- Strength and hypertrophy untested Limited evidence
No trial has shown that arginine silicate improves strength, endurance or muscle gain across a training block.
Dosage & safety
Scientific references
- Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults
- Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults
- Effects of Inositol-Enhanced Bonded Arginine Silicate Ingestion on Cognitive and Executive Function in Gamers
Where to buy
Referral link — this site may earn a commission on purchases.
Related in Physical performance
- Creatine (monohydrate) Strong evidence
- Whey Protein Strong evidence
- Caffeine Strong evidence
- Beta-Alanine Moderate evidence
- BCAA (Branched-Chain Amino Acids) Limited evidence
- EAA (Essential Amino Acids) Moderate evidence