Limited evidencePhysical performance

Methylliberine (Dynamine)

A purine alkaloid related to caffeine and theacrine, sold in pre-workouts for energy and focus. The few human trials show effects on mood but not on cognition or performance beyond what caffeine provides.

Evidence last reviewed: August 2026

What the science says

Mood and affect Limited evidence
A randomized controlled trial in healthy men and women found methylliberine improved several indices of affect but did not improve cognitive function. It was a single acute study.
Vigilance and performance with caffeine Limited evidence
A double-blind randomized placebo-controlled trial in tactical personnel testing caffeine, methylliberine and theacrine found no clear added benefit of methylliberine on vigilance or marksmanship. Combination products make the individual contribution hard to isolate.
Short-term safety Limited evidence
A randomized trial of up to 28 days found no clinically meaningful changes in heart rate, blood pressure or blood markers with methylliberine alone or combined with theacrine, in around 100 young adults. This covers safety, not efficacy.

Dosage & safety

Studied doseStudies used 100–200 mg/day, alone or with caffeine and theacrine. Product labels usually supply 25–100 mg per serving.

SafetyShort-term trials in young adults found no significant cardiovascular or blood-marker changes. It is almost always sold combined with caffeine, so stimulant side effects (jitteriness, disturbed sleep) come from the whole product. No data in adolescents, pregnancy or people with cardiovascular disease.

Scientific references

Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women
La Monica MB, Raub B, Malone K — Nutrients, 2023
Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial
Cintineo HP, Bello ML, Chandler AJ — J Int Soc Sports Nutr, 2022
Safety of Short-Term Supplementation with Methylliberine (Dynamine(®)) Alone and in Combination with TeaCrine(®) in Young Adults
VanDusseldorp TA, Stratton MT, Bailly AR — Nutrients, 2020

Where to buy

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EAA (Essential Amino Acids) Moderate evidence