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Limited evidencePhysical performance

Methylliberine (Dynamine)

A purine alkaloid related to caffeine and theacrine, sold in pre-workouts for energy and focus. The few human trials show effects on mood but not on cognition or performance beyond what caffeine provides.

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What the science says

  • Mood and affect Limited evidence

    A randomized controlled trial in healthy men and women found methylliberine improved several indices of affect but did not improve cognitive function. It was a single acute study.

  • Vigilance and performance with caffeine Limited evidence

    A double-blind randomized placebo-controlled trial in tactical personnel testing caffeine, methylliberine and theacrine found no clear added benefit of methylliberine on vigilance or marksmanship. Combination products make the individual contribution hard to isolate.

  • Short-term safety Limited evidence

    A randomized trial of up to 28 days found no clinically meaningful changes in heart rate, blood pressure or blood markers with methylliberine alone or combined with theacrine, in around 100 young adults. This covers safety, not efficacy.

Dosage & safety

Studied doseStudies used 100–200 mg/day, alone or with caffeine and theacrine. Product labels usually supply 25–100 mg per serving.
SafetyShort-term trials in young adults found no significant cardiovascular or blood-marker changes. It is almost always sold combined with caffeine, so stimulant side effects (jitteriness, disturbed sleep) come from the whole product. No data in adolescents, pregnancy or people with cardiovascular disease.

How to take it

TimingTake it earlier in the day if the product also contains caffeine, which most do.
With food?With or without food.
Worth knowingRead the caffeine content on the label before you add coffee, because the effects people attribute to methylliberine are usually caffeine's.

Interactions

With other supplements

  • caffeine

    Methylliberine is nearly always sold with caffeine, and the stimulant load, sleep disruption and jitteriness come from the caffeine total. count the caffeine in the product against your daily total

Well-established interactions only — this is not a complete list. Always tell your doctor and pharmacist what you take.

Frequently asked questions

Does methylliberine (Dynamine) work for energy and focus?

Methylliberine (Dynamine) has limited evidence: one trial found it improved mood indices but not cognitive function, and a trial in tactical personnel found no clear added benefit on vigilance or marksmanship. Effects people attribute to methylliberine are usually caffeine's.

Is methylliberine safe?

A randomised trial of up to 28 days in around 100 young adults found no clinically meaningful changes in heart rate, blood pressure or blood markers with methylliberine. There are no data in adolescents, pregnancy or cardiovascular disease.

How much methylliberine should I take?

Studies used 100–200 mg/day of methylliberine, alone or with caffeine and theacrine, while labels usually supply 25–100 mg per serving. Count the caffeine in any methylliberine product against your daily total, and take it earlier in the day.

Scientific references

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