Supplement analysis backed by scientific evidence · PT

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Limited evidenceMen's health

Men's Multivitamin

An iron-free daily formula that covers nutritional gaps. Large long-term trials in men have found essentially nothing for heart disease or cognition, and at best a very small reduction in cancer.

Evidence last reviewed: August 2026

What the science says

  • Small reduction in total cancer Moderate evidence

    The Physicians' Health Study II randomised 14,641 male physicians to a daily multivitamin for a median of 11 years and found an 8% lower incidence of total cancer. The effect was small, barely statistically significant, and has not been replicated in another trial of this size.

  • No effect on cardiovascular events Moderate evidence

    The same trial found no reduction in major cardiovascular events, myocardial infarction, stroke, or cardiovascular mortality over more than a decade of daily use.

  • No cognitive benefit in men Moderate evidence

    A randomised trial nested in the same cohort, following 5,947 men for 12 years with repeated telephone cognitive testing, found no difference between multivitamin and placebo on global cognition or verbal memory.

Dosage & safety

Studied doseOne tablet or capsule daily with food, per label. Formulas for men omit iron because men without diagnosed deficiency do not need supplemental iron and excess is harmful.
SafetyGenerally safe at label doses. Watch the fat-soluble vitamins and any high-dose single nutrients if you also take separate supplements; vitamin A above roughly 3,000 mcg RAE/day and long-term high-dose vitamin E are the usual concerns. A multivitamin does not replace investigation of a suspected deficiency.

Scientific references

Where to buy

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