Limited evidenceJoints & skin

Manjistha

An Ayurvedic root (Rubia cordifolia) traditionally used as a blood purifier for skin complaints. The only human trial measured gut bacteria, not skin, and everything else is laboratory work.

Evidence last reviewed: August 2026

What the science says

Skin conditions Limited evidence
No randomized trial of manjistha for acne, eczema, pigmentation or any other skin condition is indexed in PubMed. The traditional indication has never been formally tested in people.
Gut microbiota Limited evidence
A double-blind, randomized, placebo-controlled pilot study found that manjistha and triphala supplementation shifted the composition of the human gut microbiome. It was a small pilot with microbiome composition as the outcome, and no health endpoint was measured.
Laboratory activity Limited evidence
Reviews of the Rubia genus describe anti-inflammatory, antioxidant and cytotoxic activity of anthraquinones such as rubiadin in cell and animal models. None of this has been shown to occur at doses achievable by taking the herb orally.

Dosage & safety

Studied doseNo clinical dose is established. Traditional and label doses are 500–1,000 mg of root powder or extract once or twice daily.

SafetyRubia species contain anthraquinones, including lucidin, which has shown genotoxic and carcinogenic potential in laboratory tests; a related species, Rubia tinctorum, was withdrawn from the German market for this reason. Long-term use is not advisable without medical supervision. Avoid in pregnancy, breastfeeding and in children.

Scientific references

Modulatory Effects of Triphala and Manjistha Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
Peterson CT, Pourang A, Dhaliwal S — J Altern Complement Med, 2020
A comprehensive review of Rubia medicinal plants: Traditional uses, botany, phytochemistry, and pharmacological activities
Zhang M, Zhang J, Feng F — Ann Pharm Fr, 2026

Where to buy

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