Supplement analysis backed by scientific evidence · PT

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Limited evidenceJoints & skin

Gotu Kola

The "brain tonic" claims do not survive meta-analysis, which found no benefit in any cognitive domain. The better (though still weak) evidence is for chronic venous insufficiency, and there are credible case reports of drug-induced liver injury.

What the science says

  • Cognitive function Limited evidence

    A meta-analysis of 11 RCTs (5 of Centella alone, 6 of Centella-containing products) found no significant difference from placebo in any cognitive domain. The only positive pooled findings were short-term mood effects one hour after dosing: increased alertness (SMD 0.71, 95% CI 0.01-1.41) and decreased anger (SMD -0.81, 95% CI -1.51 to -0.09).

  • Chronic venous insufficiency Limited evidence

    A systematic review of 8 studies found that titrated Centella extract significantly improved microcirculatory parameters, including transcutaneous pO2/pCO2, rate of ankle swelling and venoarteriolar response, with reported relief of leg heaviness, pain and oedema. Most trials were old, small and inadequately reported, giving unclear risk of bias.

  • Wound healing and scars Limited evidence

    Asiaticoside and madecassoside have well-described effects on collagen synthesis in cell and animal models, and topical Centella preparations are widely used for scars and striae. Controlled human trials are few, small and mostly of topical rather than oral use.

Dosage & safety

Studied doseVenous insufficiency trials used 60-180 mg/day of titrated extract of Centella asiatica (TTFCA/TECA, standardized to roughly 40% asiaticoside). Cognitive and mood studies used 250-750 mg/day of dried leaf extract. Traditional dosing is 1-4 g/day of dried herb; European guidance suggests limiting continuous oral use to about 6 weeks.
SafetyCommon effects are mild: nausea, headache and drowsiness. The notable risk is hepatotoxicity, with multiple published case reports of cholestatic or hepatocellular hepatitis after weeks to months of oral gotu kola, resolving on withdrawal and in some cases recurring on rechallenge. Several European regulators advise limiting continuous courses to around 6 weeks and avoiding it in liver disease or alongside hepatotoxic drugs. Topical use can cause contact dermatitis. It may add to sedatives and, theoretically, to hypoglycaemic and lipid-lowering drugs. Avoid in pregnancy and breastfeeding.

Scientific references

Where to buy

NOW Foods, Gotu Kola, 450 mg, 100 Veg Capsules

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