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Limited evidenceSleep & relaxation

Wild Lettuce

Wild lettuce ("lettuce opium") is marketed as a natural opioid alternative, which it is not — its lactones are sedative in mice at high doses and have no affinity for opioid receptors. Human evidence is one small pilot study on a different lettuce species.

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What the science says

  • Relieves pain like an opioid Limited evidence

    The name lactucarium and the milky latex fuel an opium comparison that the pharmacology does not support. In mice, lactucin and lactucopicrin at 15-30 mg/kg produced analgesia in the hot-plate test comparable in size to ibuprofen 60 mg/kg, and lactucin-type guaianolides also reduced spontaneous movement — sedative and mildly analgesic, but not opioid-receptor mediated and never tested in humans.

  • Improves sleep and reduces anxiety Limited evidence

    The only human data are a 60-person pilot of Lactuca sativa (garden lettuce) seed oil, 1000 mg for one week, which reported better sleep and anxiety scores than placebo on verbal questionnaires. That study used a different species, a different plant part, a one-week duration and unvalidated outcome tools, so it cannot be extended to wild lettuce extracts.

  • Is a safe legal high Limited evidence

    Recreational use of wild lettuce extracts and smoking preparations has generated poison-centre reports of nausea, vomiting, dizziness, sweating, blurred vision and, at high doses, confusion and respiratory depression. There is no established recreational dose and no human pharmacokinetic data.

Dosage & safety

Studied doseNo human-validated dose exists for wild lettuce (Lactuca virosa). Traditional herbal texts list 0.5-3 g of dried leaf as tea or 0.25-1 mL of tincture; the only relevant human trial used 1000 mg/day of Lactuca sativa seed oil, a different preparation entirely. Concentrated "lactucarium" resins and extracts on the market have unknown and highly variable lactone content.
SafetyDocumented adverse effects, mostly from high-dose or recreational use, include nausea, vomiting, dizziness, sweating, tachycardia, pupil dilation, blurred vision, urinary retention, confusion and — at large doses — respiratory depression, with hospitalisations reported. Wild lettuce latex is irritant to skin and mucous membranes. It is a member of the Asteraceae family, so it can cross-react in people allergic to ragweed, chrysanthemum or daisies. Additive sedation with alcohol, benzodiazepines, opioids, antihistamines and other sedatives is the main interaction concern. Avoid before driving, in pregnancy and breastfeeding, in glaucoma (anticholinergic-like effects reported), and in benign prostatic hyperplasia. Not a substitute for medically managed pain treatment.

How to take it

TimingEvening only, about an hour before bed.
With food?Either way.
Worth knowingDo not drive after taking it, and treat concentrated "lactucarium" extracts as unknown strength — the reported hospitalisations came from high doses.

Interactions

With medications

  • benzodiazepines, opioids, z-drugs, sedating antihistamines and alcohol

    Additive sedation, with respiratory depression reported at high wild lettuce doses. do not combine

  • anticholinergic drugs

    Additive dry mouth, blurred vision and urinary retention, which matters in glaucoma and prostate enlargement. avoid combining

With other supplements

  • valerian, kava, melatonin and other sedating supplements

    Additive next-morning grogginess and sedation. do not stack sedatives

Well-established interactions only — this is not a complete list. Always tell your doctor and pharmacist what you take.

Frequently asked questions

Is wild lettuce a natural opioid?

No: wild lettuce lactones have no affinity for opioid receptors and have never been tested for pain relief in humans (limited evidence). In mice, high doses were sedative and mildly analgesic, comparable in size to ibuprofen.

Does wild lettuce help you sleep?

The only human sleep data come from a 60-person, one-week pilot of garden lettuce seed oil, a different species and plant part (limited evidence). That study cannot be extended to wild lettuce extracts.

Is wild lettuce safe?

Wild lettuce, especially at high or recreational doses, has caused nausea, vomiting, dizziness, blurred vision, confusion and respiratory depression, with hospitalisations reported. Do not drive after taking it, and avoid it in pregnancy, glaucoma and prostate enlargement.

Can I take wild lettuce with sleeping pills or alcohol?

Do not combine wild lettuce with benzodiazepines, opioids, z-drugs, sedating antihistamines or alcohol, because sedation adds up and respiratory depression has been reported at high doses. Avoid stacking it with valerian, kava, melatonin or other sedating supplements.

Scientific references

Where to buy

Bio Nutrition, Sleep Wellness with Wild Lettuce Extract, 60 Vegetarian Capsules

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