Lipase
The fat-splitting enzyme sold to make heavy meals more comfortable. Two small crossover trials in healthy people found measurable effects, which is a thin base for such a widely sold product.
Evidence last reviewed: August 2026
What the science says
- Fullness after a fatty meal Limited evidence
In a crossover study in healthy volunteers, lipase taken before a high-fat meal reduced sensations of fullness and bloating. The study was small and measured perceptions rather than actual digestion.
- Nutrient handling after a meal Limited evidence
A randomized, double-blind, placebo-controlled crossover trial found an oral multienzyme supplement altered postprandial plasma nutrient concentrations in healthy middle-aged and older adults. Whether that produces any symptom benefit was not established.
Dosage & safety
Scientific references
- Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects
- Oral Multienzyme Supplementation Alters Postprandial Plasma Nutrient Concentrations after a Mixed Meal in Healthy Middle-Aged and Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Where to buy
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