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Limited evidenceLongevity & antioxidants

Kaempferol

A common dietary flavonol from kale, tea and capers with abundant laboratory activity. There are no clinical trials of isolated kaempferol, and the human data are observational associations with diet.

Evidence last reviewed: August 2026

What the science says

  • Anti-inflammatory activity Limited evidence

    A review of kaempferol and inflammation summarizes consistent suppression of NF-κB and inflammatory mediators across cell and animal models. None of this has been tested with a purified kaempferol supplement in a human trial.

  • Dietary flavonol intake and mortality Limited evidence

    An analysis of NHANES data found higher dietary flavonol intake, including kaempferol, associated with lower all-cause mortality. This is an observational association in people eating flavonol-rich diets and cannot be attributed to kaempferol itself or to supplements.

Dosage & safety

Studied doseNo studied supplement dose. Capsules typically supply 25–100 mg/day as a label dose. Dietary intake from a flavonol-rich diet is roughly 5–20 mg/day; oral bioavailability of isolated kaempferol is low.
SafetyDietary amounts are safe. Isolated high-dose kaempferol has no human safety record. Flavonols can inhibit CYP enzymes and sulfotransferases in vitro, raising a theoretical interaction risk with medication. Avoid in pregnancy and breastfeeding.

Scientific references

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