Limited evidenceJoints & skin

Copaiba Oil

An Amazonian tree resin rich in beta-caryophyllene, marketed for inflammation and skin. Only two small clinical studies exist, both topical and both on skin conditions rather than joints.

Evidence last reviewed: August 2026

What the science says

Topical use for acne Limited evidence
A double-blind placebo-controlled trial applied a 3% copaiba essential oil preparation to the skin and reported a reduction in the area affected by acne lesions. The study was small and has not been replicated.
Anti-inflammatory and skin effects Limited evidence
A phytochemical study of Copaifera langsdorffii oleoresin included a preliminary in vivo evaluation suggesting an antipsoriatic effect. Beyond this, the anti-inflammatory case rests on beta-caryophyllene acting at the CB2 receptor in laboratory models, not on human joint trials.

Dosage & safety

Studied doseNo established oral dose. Studied topically at about 3% in a carrier. Oral copaiba capsules typically supply 250–500 mg of oleoresin as a label dose only.

SafetyUndiluted resin can irritate skin; dilute before topical use and patch test. Oral use in larger amounts has been linked to nausea and abdominal discomfort. Avoid in pregnancy and breastfeeding, and do not use essential oil products internally without professional guidance.

Scientific references

Application of the essential oil from copaiba (Copaifera langsdori Desf.) for acne vulgaris: a double-blind, placebo-controlled clinical trial
da Silva AG, Puziol Pde F, Leitao RN — Altern Med Rev, 2012
GC-MS profiling of the phytochemical constituents of the oleoresin from Copaifera langsdorffii Desf. and a preliminary in vivo evaluation of its antipsoriatic effect
Gelmini F, Beretta G, Anselmi C — Int J Pharm, 2013

Where to buy

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