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Limited evidenceHeart & metabolic

Celery Seed Extract

A standardized celery seed extract lowered blood pressure substantially in a small crossover trial, but essentially all the human data come from one research team. Promising, not established - and the gout and arthritis claims have no trial support at all.

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What the science says

  • Lowered blood pressure in hypertensive patients Limited evidence

    In 52 hypertensive patients taking 1.34 g/day celery seed extract for 4 weeks in a triple-blind crossover trial with 24-hour ambulatory monitoring, systolic pressure fell from 141.2 to 130.0 mmHg and diastolic from 92.2 to 84.2 mmHg, with no significant change on placebo. An 11 mmHg systolic drop rivals a first-line antihypertensive drug, which is itself a reason to withhold judgment until independent groups replicate it.

  • Improved anxiety and depression scores Limited evidence

    The same group ran a 4-week crossover trial in 50 hypertensive patients at the same 1.34 g/day dose: Beck Anxiety Inventory scores fell by 6.78 points and Beck Depression Inventory scores by 3.63 points versus placebo. Blood pressure also fell in the same patients, so mood improvement may be partly secondary, and this is a single exploratory finding.

  • Gout, uric acid and joint pain Limited evidence

    Celery seed is widely sold for gout and arthritis on the strength of in vitro and animal work on apigenin and 3-n-butylphthalide. No adequate human trials test celery seed extract for uric acid, gout flares or joint pain.

Dosage & safety

Studied dose1.34 g/day of a standardized seed extract (four capsules daily) in both published hypertension trials. Many commercial products instead supply 75-150 mg of a concentrated extract standardized to 3-n-butylphthalide - a dose with no direct outcome data behind it.
SafetyCelery is a recognized allergen (it is a mandatory labeled allergen in the EU) and can trigger anaphylaxis in sensitized people, including via birch-mugwort-celery cross-reactivity. Furocoumarins in celery can cause photosensitivity. The extract may add to antihypertensive and diuretic medications, so monitor blood pressure if combining. Avoid in pregnancy given traditional uterine-stimulant use and no safety data, and in active kidney inflammation.

How to take it

TimingSplit across the day — the trials used four capsules daily rather than a single dose.
With food?With food; concentrated seed extract can irritate an empty stomach.
Worth knowingIf you react to birch or mugwort pollen, celery cross-reactivity is real — this is one of the few supplements documented to cause anaphylaxis.

Interactions

With medications

  • antihypertensive medication

    additive blood-pressure lowering monitor blood pressure if you combine them, and tell your prescriber

  • diuretics

    celery seed has a mild diuretic effect that can add to the drug's watch for dizziness and electrolyte changes

  • photosensitizing drugs (doxycycline, amiodarone, some diuretics)

    furocoumarins in celery add to drug-induced sun sensitivity use sun protection, particularly in the first weeks

Well-established interactions only — this is not a complete list. Always tell your doctor and pharmacist what you take.

Frequently asked questions

Does celery seed extract lower blood pressure?

Celery seed extract lowered blood pressure substantially in one small crossover trial of 52 hypertensive patients, but essentially all the human data come from one research team, so the evidence is limited. The effect was large enough that it needs independent replication before being trusted.

Does celery seed help gout or arthritis?

No adequate human trials test celery seed extract for uric acid, gout flares or joint pain. Those claims rest on lab and animal work only.

How much celery seed extract per day?

Both published hypertension trials used 1.34 g/day of a standardized celery seed extract, taken as four capsules daily. Many commercial products supply 75-150 mg of a concentrated extract instead, a dose with no direct outcome data.

Is celery seed extract safe with blood pressure medication?

Celery seed extract may add to the effect of antihypertensive and diuretic drugs, so monitor your blood pressure and tell your prescriber if you combine them. Celery is also a recognized allergen that can cause anaphylaxis, including in people sensitive to birch or mugwort pollen.

Scientific references

Where to buy

NOW Foods, Celery Seed Extract, 60 Veg Capsules

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