Supplement analysis backed by scientific evidence · PT

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Moderate evidenceWeight management

Cayenne (Capsaicin)

The pungent compound in chilli peppers, which measurably raises energy expenditure and slightly lowers food intake. The effects are real but small enough that they rarely translate into meaningful weight loss.

Evidence last reviewed: August 2026

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What the science says

  • Reduced energy intake Moderate evidence

    A systematic review and meta-analysis of energy intake data found capsaicinoids reduce ad libitum energy intake by roughly 70–75 kcal per meal. Whether that deficit persists over weeks was not established.

  • Energy expenditure and body weight Moderate evidence

    A meta-analysis of human studies found capsaicin and capsiate increase energy expenditure and can produce small reductions in abdominal fat and body weight. Effect sizes were small and trials were mostly short.

  • Long-term weight loss Limited evidence

    No long trial shows clinically meaningful weight loss from capsaicin alone. Thermogenic effects also attenuate with habitual chilli consumption.

Dosage & safety

Studied doseTrials used roughly 2–10 mg/day of capsaicinoids, or 6 mg/day of capsaicin in several studies; non-pungent capsiate has been used at similar amounts. Enteric-coated forms are gentler on the stomach.
SafetyBurning mouth, heartburn, stomach pain and diarrhoea are common, and high doses can aggravate reflux, gastritis and haemorrhoids. Capsaicin may interact with anticoagulants and with theophylline absorption. People with active peptic ulcer or inflammatory bowel disease should be careful.

Scientific references

Where to buy

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