Supplement analysis backed by scientific evidence · PT

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Limited evidenceLongevity & antioxidants

Anserine

A histidine dipeptide abundant in fish and poultry, sold with carnosine for brain ageing and fatigue. Two small Japanese randomised trials suggest a memory effect; the uric acid claims are animal-only.

Evidence last reviewed: August 2026

What the science says

  • Memory in older adults Limited evidence

    A randomised trial of an anserine-carnosine supplement in elderly volunteers reported preserved verbal episodic memory over three months, and a second randomised trial in people with mild cognitive impairment found effects mainly in APOE4 carriers. Both were small, single-country studies with subgroup-dependent results.

  • Carnosine and cognition more broadly Limited evidence

    A 2026 systematic review and meta-analysis of carnosine for cognitive function and mental health found the trial base small and heterogeneous, with effects that did not consistently reach significance across outcomes.

  • Uric acid and fatigue Limited evidence

    The uric-acid claim comes from rodent work showing anserine influenced renal aquaporin expression in hyperuricaemic mice. There is no human trial of anserine for uric acid or for fatigue.

Dosage & safety

Studied doseThe cognition trials used roughly 750-1,000 mg/day of a combined anserine-carnosine preparation (commonly 500 mg anserine plus 250 mg carnosine) for 12 weeks to three months.
SafetyWell tolerated in the published trials, with no notable adverse effects reported. Products are usually derived from fish or chicken, so they are unsuitable for vegetarians and for people with fish or poultry allergy. Histidine dipeptides are purine-related compounds; despite the marketing, people with gout should not assume a benefit and should discuss use with a doctor. No data in pregnancy or childhood.

Scientific references

Where to buy

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