Supplement analysis backed by scientific evidence · PT

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Moderate evidenceBrain & cognition

Migraine Support Formulas

Blends of riboflavin, magnesium, CoQ10 and herbs for migraine prevention. The main ingredients have meta-analysis support at specific doses; the benefit is real but modest, and many blends underdose them.

Evidence last reviewed: August 2026

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What the science says

  • Riboflavin for attack frequency Moderate evidence

    A systematic review and meta-analysis found that vitamin B2 supplementation reduced migraine frequency and duration in adults, though not consistently in children. The trials were small and used a high dose of 400 mg/day.

  • Magnesium for prevention Moderate evidence

    A meta-analysis of randomized controlled trials concluded that oral magnesium reduces migraine frequency and intensity, and that intravenous magnesium relieves acute attacks. Effect sizes were moderate and trial quality was variable.

  • Supplements as a class Moderate evidence

    A systematic review with dose-response meta-analysis of dietary supplements for migraine prophylaxis found benefit for several agents including magnesium, riboflavin and coenzyme Q10, with heterogeneity across trials and generally low to moderate certainty.

Dosage & safety

Studied doseStudied doses are riboflavin 400 mg/day, magnesium 400–600 mg/day of elemental magnesium, and coenzyme Q10 300 mg/day. Prevention takes 8–12 weeks to judge. Check that a blend actually contains these amounts rather than token quantities.
SafetyRiboflavin at 400 mg is well tolerated and turns urine bright yellow. Magnesium commonly causes diarrhoea at these doses and accumulates in kidney impairment. Feverfew and butterbur, sometimes included, carry their own risks — unpurified butterbur contains hepatotoxic pyrrolizidine alkaloids and should be avoided unless certified PA-free. New, severe or changed headaches need medical assessment rather than a supplement.

Scientific references

Where to buy

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