Supplement analysis backed by scientific evidence · PT

← All supplements
Limited evidenceHeart & metabolic

Ligusticum (Chuan Xiong)

A traditional Chinese root used for headache and blood flow. The trials that exist test multi-herb decoctions or an injectable isolated alkaloid, not the capsules sold as supplements.

Evidence last reviewed: August 2026

What the science says

  • Migraine Limited evidence

    A meta-analysis restricted to 19 higher-quality randomised trials (1832 participants) found chuanxiong-containing formulae reduced migraine frequency, duration and pain severity. Every trial tested a multi-herb formula, so the effect cannot be attributed to chuanxiong alone, and all were conducted in China.

  • Angina and blood flow Limited evidence

    A meta-analysis of ligustrazine, an alkaloid derived from the herb, as adjunctive therapy for angina reported benefit, but ligustrazine was given by intravenous injection in hospital, which tells you nothing about an oral extract.

  • Stroke prevention Limited evidence

    A Cochrane review of chuanxiong preparations for preventing stroke was withdrawn rather than updated, leaving no current systematic evidence for this use.

Dosage & safety

Studied doseTraditional decoctions use 3–10 g of dried root per day, generally within a multi-herb formula. Western capsules typically supply 500–1000 mg of extract; no dose-finding data support this.
SafetyChuanxiong has antiplatelet activity and may increase bleeding risk with warfarin, aspirin or other anticoagulants; stop before surgery. It is traditionally avoided in pregnancy and in heavy menstrual bleeding. Reported side effects include headache, dizziness and gastrointestinal upset. Quality control of imported herbs varies.

Scientific references

Where to buy

View on iHerb

Referral link — this site may earn a commission on purchases.

Related in Heart & metabolic