Supplement analysis backed by scientific evidence · PT

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Moderate evidenceHeart & metabolic

Homocysteine Support Formulas

B6, B12 and folate combinations reliably lower homocysteine. Large trials then showed that lowering the marker does not lower heart attacks or death, with a small possible benefit for stroke.

Evidence last reviewed: August 2026

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What the science says

  • Homocysteine falls reliably Moderate evidence

    A meta-regression of randomised controlled trials of vitamin B12, alongside trials of folate and B6, shows consistent dose-related reductions in plasma homocysteine. The biochemical effect is not in doubt.

  • No reduction in cardiovascular events or death Moderate evidence

    A Cochrane review of homocysteine-lowering interventions covering tens of thousands of participants found no reduction in myocardial infarction, cardiovascular death or all-cause mortality.

  • Possible small stroke benefit Limited evidence

    A meta-analysis of 21 randomised trials of folic acid found a modest reduction in stroke, concentrated in populations with low baseline folate status and no food fortification.

Dosage & safety

Studied doseTrials typically used 0.4–2.5 mg folic acid, 25–50 mg vitamin B6 and 0.4–1 mg vitamin B12 daily. Methylfolate is often sold for people with MTHFR variants without evidence it improves outcomes over folic acid.
SafetyGenerally well tolerated. Folic acid can mask B12 deficiency anaemia while nerve damage progresses, so B12 status should be checked first. Long-term B6 above roughly 100 mg/day can cause peripheral neuropathy. Some trials in people with kidney disease or recent stenting reported worse outcomes.

Scientific references

Where to buy

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