Celastrus Paniculatus
The 'intellect tree' of Ayurveda, sold as a seed oil for memory. The entire cognitive case rests on rodent experiments — there is no published human trial.
Evidence last reviewed: August 2026
What the science says
- Memory in animal models Limited evidence
Rodent studies report that Celastrus paniculatus seed oil reverses scopolamine-induced deficits in navigational memory and improves passive-avoidance learning while altering monoamine turnover. These are animal findings at doses not translated to humans.
- No human evidence Limited evidence
An extensive review of the phytochemistry, traditional uses and pharmacology of Celastrus paniculatus identifies no controlled clinical trial of cognition in humans, leaving the marketed benefits unverified.
Dosage & safety
Studied doseTraditional use is 1–2 g/day of seed powder, or a small number of seeds, sometimes as an oil. No dose has been established in humans and the seed oil is potent — start low if you use it at all.
SafetyHuman safety data are essentially absent. The seed oil is a strong stimulant and irritant in traditional accounts, and overdose has been described as causing sweating, agitation and nausea; the plant is a member of a family containing toxic constituents. Avoid in pregnancy, breastfeeding, in children, and alongside stimulants or sedatives. Celastrus paniculatus is also listed as endangered in parts of its range.
Scientific references
Where to buy
Referral link — this site may earn a commission on purchases.
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