Supplement analysis backed by scientific evidence · PT

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Limited evidenceHeart & metabolic

Arjuna

Arjuna bark is the classic Ayurvedic heart herb, and it is well tolerated, but the best-designed trial to date failed its primary endpoint in heart failure. It is not a substitute for evidence-based cardiac therapy.

What the science says

  • Improves heart function in chronic heart failure Limited evidence

    The most rigorous test is a 100-patient double-blind, placebo-controlled add-on trial at AIIMS: 750 mg of standardized aqueous bark extract twice daily for 12 weeks in NYHA class II patients with ejection fraction 40% or below. It did not change the primary endpoint of LVEF (24.3% vs 25.5%, p=0.4), nor BNP, nor the inflammatory markers. Only scattered post-hoc subgroup and antioxidant findings were positive, which is not a basis for a treatment claim.

  • Reduces angina episodes Limited evidence

    Older small Indian trials from the 1990s reported fewer anginal episodes and improved treadmill time with 500 mg every 8 hours, but these were mostly small, poorly blinded, and never replicated in a modern multicentre trial. Reviewers consistently describe the evidence base as promising but methodologically weak.

  • Improves cholesterol and blood pressure Limited evidence

    Reported reductions in total and LDL cholesterol are inconsistent across small studies, and blood pressure effects are minor where they appear at all. No meta-analysis supports a clinically meaningful lipid or blood pressure effect.

Dosage & safety

Studied doseTrials have used 500 mg of bark powder or extract two to three times daily; the AIIMS heart failure trial used 750 mg of standardized aqueous extract twice daily (1500 mg/day) for 12 weeks. Products vary widely in extract strength and standardization, so label doses are not comparable across brands.
SafetyGenerally well tolerated in trials, with mild gastrointestinal upset and occasional headache the main complaints; the AIIMS trial found no safety signal over 12 weeks. Because it is used alongside real cardiac drugs, the practical risks are interaction and substitution: monitor if you take antihypertensives, beta-blockers, antiplatelets or anticoagulants, and never stop prescribed heart failure medication in favour of arjuna. Long-term safety beyond a few months is not established, and thyroid-suppressing effects have been suggested in animal work. Avoid in pregnancy and breastfeeding for lack of data.

Scientific references

Where to buy

Amazing India, Arjuna Bark, Standardized Extract, 500 mg, 120 Veggie Capsules

View on iHerb

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