Supplement analysis backed by scientific evidence · PT

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Moderate evidenceWeight management

Allulose

A rare sugar that tastes close to sucrose but is barely metabolised, so it contributes almost no calories. It reliably blunts the glucose and insulin rise after a meal; what it has not been shown to do is reduce body weight or long-term HbA1c.

Evidence last reviewed: August 2026

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What the science says

  • Lowers postprandial glucose and insulin Moderate evidence

    A 2026 systematic review and meta-analysis of 20 controlled human trials (1,033 participants) found allulose significantly reduced postprandial glucose and insulin area under the curve, both rated moderate certainty. Twelve of the trials tested allulose specifically.

  • No effect on fasting glucose, HbA1c or body composition Moderate evidence

    The same meta-analysis found no significant effects on HbA1c, fasting glucose or insulin, blood lipids, uric acid or measures of adiposity, with very low to moderate certainty. Its value is as a sugar substitute, not as a weight-loss or metabolic agent in its own right.

  • Blunts the response to a sugar load Moderate evidence

    A randomized cross-over trial found that adding allulose to a standard oral sucrose load improved glucose tolerance and reduced the insulin response in healthy adults. A separate randomized study confirmed acute metabolic effects and acceptable tolerability at typical serving sizes.

Dosage & safety

Studied doseTrials use roughly 5–15 g per serving, often taken with or just before a carbohydrate-containing meal; catalytic-dose studies used as little as 5 g. In cooking it substitutes for sugar at roughly 1.3 times the weight, since it is about 70% as sweet.
SafetyGenerally well tolerated below about 0.4 g/kg per single dose; above that, bloating, gas, abdominal discomfort and diarrhoea become common, as with other poorly absorbed sugars. It is largely excreted unchanged in urine. It does not appear to raise blood glucose, but people with diabetes on insulin should still monitor when changing sweeteners. Regulatory status differs by country: accepted in the US, still restricted as a novel food in the EU and UK.

Scientific references

Where to buy

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