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Limited evidenceWomen's health

Pomegranate Seed Oil

A punicic-acid-rich oil marketed for menopausal symptoms. The one placebo-controlled trial did not find a clear benefit on its main outcome, and supportive data come from a weaker cohort design.

Evidence last reviewed: August 2026

What the science says

  • Menopausal symptoms Limited evidence

    A randomized, double-blind, placebo-controlled trial in women with menopausal symptoms did not demonstrate a clear advantage over placebo on the primary symptom outcome. This is the only placebo-controlled test of the oil for this use.

  • Symptom relief in uncontrolled follow-up Limited evidence

    An individually controlled cohort study later reported improvement in menopausal symptom scores with pomegranate seed oil. Without randomization or blinding this design cannot separate the oil from expectation and time.

Dosage & safety

Studied doseThe randomized trial used capsules supplying roughly 30 mg of punicic acid twice daily for 12 weeks. Retail products vary; typical label doses are 500-1000 mg of oil daily.
SafetyGenerally well tolerated, with mild digestive complaints the main report. Because of possible weak phytoestrogenic activity, caution is reasonable in hormone-sensitive cancers. Not studied in pregnancy or breastfeeding.

Scientific references

Where to buy

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