Supplement analysis backed by scientific evidence · PT

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Limited evidenceGeneral health

Liu Wei Di Huang Wan

A six-herb Chinese formula used for centuries as a kidney-yin tonic. Meta-analyses of it as an add-on to conventional treatment report benefits in diabetic kidney disease and cognition, but almost all the trials are small, Chinese-language and at high risk of bias.

Evidence last reviewed: August 2026

What the science says

  • Add-on for cognitive impairment Limited evidence

    A 2026 systematic review and meta-analysis of Liuwei Dihuang as adjunctive therapy for cognitive impairment reported improvement over conventional therapy alone. The included trials were small and largely lacked blinding, so the pooled effect is not reliable.

  • Add-on in early diabetic nephropathy Limited evidence

    A systematic review and meta-analysis of Liuwei Dihuang pills in early diabetic nephropathy found reductions in urinary albumin markers when added to standard care. Trial quality was low and publication bias in this literature is well documented.

Dosage & safety

Studied doseTraditional dose is about 8 concentrated pills (roughly 6 g of the formula) two or three times daily, or the equivalent decoction. Trials used varied preparations, so doses are not standardised.
SafetyGenerally well tolerated; digestive upset and loose stools are the usual complaints. Product quality varies widely and imported patent medicines have been found adulterated with pharmaceuticals. Not a replacement for treatment of diabetes or kidney disease, and interactions with antidiabetic drugs are plausible.

Scientific references

Where to buy

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