Yokukansan
A seven-herb Japanese Kampo formula used in dementia care for agitation, delusions and hallucinations. Meta-analyses of randomized trials show a modest benefit on some behavioural symptoms, mainly in Japanese studies of limited quality.
Evidence last reviewed: August 2026
What the science says
- Improvement in behavioural and psychological symptoms of dementia Moderate evidence
An updated meta-analysis of randomized controlled trials found yokukansan improved Neuropsychiatric Inventory scores compared with control, with the clearest effects on delusions, hallucinations and agitation. Trials were mostly small, Japanese, and often not blinded.
- No clear effect on cognition or daily function Moderate evidence
The same meta-analyses found no significant benefit on cognitive test scores, and effects on activities of daily living were inconsistent. Yokukansan is a symptom-management option, not a treatment for the underlying disease.
- Better tolerated than antipsychotics in these trials Limited evidence
Pooled analyses reported fewer adverse events and less discontinuation than with antipsychotic comparators. The comparisons were rarely blinded and follow-up was short.
Dosage & safety
Scientific references
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