Supplement analysis backed by scientific evidence · PT

← All supplements
Limited evidenceMen's health

Post-Cycle Therapy Formulas

Over-the-counter blends sold to restart natural testosterone after a prohormone or steroid cycle. The drugs that actually do this are prescription medicines such as clomiphene; no supplement blend has been shown in a controlled trial to speed recovery of the hypothalamic-pituitary-gonadal axis.

Evidence last reviewed: August 2026

What the science says

  • No controlled evidence for supplement blends Limited evidence

    There are no randomized trials of over-the-counter post-cycle supplements for restoring testosterone or LH after anabolic steroid use. The ingredients typically used (tribulus, D-aspartic acid, fenugreek, zinc) have no demonstrated effect on suppressed gonadal axis recovery.

  • The studied intervention is a prescription drug Limited evidence

    A 2026 review of clomiphene citrate in off-label post-cycle therapy summarizes the mechanism and available data, which come mostly from small uncontrolled series rather than randomized trials. Even for the drug, high-quality evidence is thin.

  • Most men recover with time, not products Limited evidence

    A retrospective study of men attending a specialist clinic after stopping anabolic steroids found reproductive hormones normalized in a substantial proportion over months, with duration and type of use predicting recovery. A separate survey of 470 men found self-reported post-cycle therapy use was associated with fewer withdrawal symptoms, but self-report surveys cannot separate cause from expectation.

Dosage & safety

Studied doseNo validated supplement dose exists, because no blend has been tested for this purpose. Anyone with suppressed testosterone after a cycle should be assessed by an endocrinologist rather than self-treating.
SafetyThe main risk is the delay: relying on a supplement can postpone proper evaluation of hypogonadism, infertility, elevated haematocrit, dyslipidaemia and cardiac effects caused by the cycle itself. Some products in this category have been found adulterated with SARMs, aromatase inhibitors or prescription anti-oestrogens. Not appropriate in any form for people under 18.

Scientific references

Where to buy

View on iHerb

Referral link — this site may earn a commission on purchases.

Related in Men's health