Supplement analysis backed by scientific evidence · PT

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Moderate evidenceGut health

Bacillus Clausii

A spore probiotic used for decades in Europe and Latin America, mostly as Enterogermina. Meta-analyses in children with acute diarrhea show a modest shortening of illness; evidence in adults is thinner.

Evidence last reviewed: August 2026

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What the science says

  • Acute diarrhea in children Moderate evidence

    A systematic review and meta-analysis of randomized controlled trials found that B. clausii shortened the duration of acute diarrhea in children by roughly a day, though the individual trials were of variable quality. A later comprehensive review and meta-analysis of the Enterogermina preparation reached similar conclusions.

  • Antibiotic-associated diarrhea Limited evidence

    A systematic review of the four-strain B. clausii preparation for preventing antibiotic-associated diarrhea and gastrointestinal side effects found supportive but mostly non-randomized or small studies, weaker than the evidence for S. boulardii or L. rhamnosus GG.

  • Antibiotic resistance as a feature Limited evidence

    The commercial strains are naturally resistant to several antibiotics, which is why the product is taken alongside antibiotic therapy; whether that translates into better clinical outcomes has not been firmly established.

Dosage & safety

Studied doseTypical trials used 2 billion spores per vial, two to three times daily, for 5–10 days in acute diarrhea.
SafetyWell tolerated, with a long record of use. Rare bacteremia has been reported in immunocompromised patients and those with central lines. Persistent, bloody or severe diarrhea, and dehydration in young children, need medical care rather than a probiotic alone.

Scientific references

Where to buy

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